Saw Palmetto has been used for centuries due to its potent anti-inflammatory properties that help alleviate symptoms associated with prostate enlargement. A review published in the Cochrane Database of Systematic Reviews concluded that saw palmetto improves urinary symptoms and flow measures compared to placebo. It also serves as a rich source of antioxidants to combat oxidative stress. The saw palmetto in Youthful Prostate is sourced in its most potent form for maximum effectiveness.

Renowned for its use in traditional African medicine, Pygeum Africanum is packed with anti-inflammatory properties that help reduce prostate inflammation and improve urinary flow. Plus it's been shown to inhibit the production of dihydrotestosterone (or DHT), which leads to benign prostatic hyperplasia (BPH). Studies have demonstrated the efficacy of Pygeum Africanum extract in improving urinary symptoms, reducing nocturia (nighttime urination), and enhancing overall quality of life in men with BPH. A meta-analysis published in the journal Prostate Cancer and Prostatic Diseases in 2018 pooled data from 11 randomized controlled trials and found that Pygeum Africanum extract significantly improved urinary symptoms and flow measures compared to placebo. Another study published in the journal Phytomedicine in 2017 reported similar findings.

Nettle extract is rich in bioactive compounds such as phytosterols, flavonoids, and lignans, and exerts anti-inflammatory effects that can help alleviate symptoms associated with BPH. Plus, it inhibits the enzyme responsible for converting testosterone to DHT, thereby reducing the risk of prostate enlargement. A systematic review and meta-analysis published in the journal Phytotherapy Research in 2020 concluded that nettle extract significantly improved urinary symptoms and flow measures in men with BPH compared to placebo. Another study published in the journal Current Therapeutic Research in 2021 reported similar findings, highlighting the potential of nettle extract as a valuable therapeutic agent for prostate health.

Research has shown that boron supplementation can help regulate hormonal balance -- particularly by modulating levels of testosterone and estrogen -- which is crucial for maintaining prostate health and preventing conditions like BPH or more serious issues. Moreover, boron has demonstrated anti-inflammatory properties, which can alleviate inflammation in the prostate gland and reduce the risk of prostate-related disorders. A study published in the journal Biological Trace Element Research in 2011 found that boron supplementation improved prostate-specific antigen -- or PSA -- levels, a marker for prostate health, in men with BPH. Another study published in the Journal of Trace Elements in Medicine and Biology in 2019 reported similar findings, suggesting that boron supplementation could help prevent significant prostate problems.

Maca is native to South America and renowned for its ability to improve erectile dysfunction and sexual performance. It’s been used by the Andean people for over 2,000 years for things like respiratory conditions and rheumatic disease. It’s an adaptogen, meaning it helps increase overall energy and vitality, which directly benefits sexual health. A study published in Andrologia found that men who used maca every day experienced a significant increase in sexual desire compared to those who took a placebo. Another study in the Asian Journal of Andrology evaluated the effects of maca on semen parameters. The study concluded that maca supplementation significantly improved sperm concentration, motility, and volume after four months of treatment. And research published in The Journal of Urology examined the effects of maca root on men with mild erectile dysfunction. The results indicated that maca improved sexual performance and overall satisfaction compared to a placebo.

These three nutrients offer superior antioxidant support, which is critical for preventing serious prostate issues from developing. A meta-analysis published in the journal Critical Reviews in Food Science and Nutrition in 2017 analyzed 26 studies and concluded that lycopene supplementation was effective in reducing PSA levels, a critical marker for prostate health in men with BPH or more serious prostate issues. The British Journal of Nutrition in 2015 pooled data from 13 studies and found that higher dietary intake of vitamin E was associated with a reduced risk of developing major prostate problems. And in 2019, the journal Nutrients found that grape seed extract improved urinary symptoms and flow measures, as well as reducing PSA levels.